Pinpointing Molecular Response.

Arpeggio Biosciences leverages state of the art sequencing approaches coupled with powerful machine learning to uncover novel insights into a compound’s biological mechanism of action.

 
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Arpeggio tests clients' compound against diverse biological backgrounds.

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Nascent RNA is isolated and prepared for next-generation sequencing.

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Our proprietary algorithm is used to identify genes, enhancers, and key regulatory factors.

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The client receives actionable insights into their compound’s mechanism of action.

 
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Arpeggio's Clarion™ Technology

provides valuable insight into a compound's mechanism of action by identifying the direct transcriptional targets of a drug in fifteen minutes or less while also capturing a snapshot of cell state at any given time.  By combining nascent sequencing with proprietary algorithms, we identify not only direct gene targets, but also transcription factor and enhancer RNA activity not attainable by any other technologies.

 

Clear.

Clarion delivers clearer results, with 20x-100x better signal-to-noise RNA detection than RNA-seq.

Complete.

Simultaneous detection of all enhancer RNA elements reveals what genes have changed and why.

Systematic.

Antibody-free and unbiased determination of the activity states of all transcription factors.